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Sigma-Aldrich Bi-2865
List Price
$109.00
Your Price
$109.00
Sigma-Aldrich Bi-2865 - SIALUPENN (Additional S&H or Hazmat Fees May Apply)
NETA PART:
SIALUPENN-SML4151-5MG
MFG.PART:
SML4151-5MG
UNSPSC:
12350000
Manufacturer:
Sigma-Aldrich
Quality Level
100
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
NC(S1)=C(C#N)C2=C1CCC[C@]2(C)C3=NC(C4=NC(O[C@@H](C)[C@]5([H])CCCN5C)=CC=N4)=NO3
Application
BI-2865 may be used for studying the Kirsten rat sarcoma virus (KRAS) signaling pathways and their role in cancer. Its selective inhibition of KRAS is used to probe the biological functions of KRAS, its mutants, and downstream signaling pathways to gain a deeper understanding of KRAS-related oncogenesis.
Biochem/physiol Actions
Cell penetrant, selective and potent pan-KRAS inhibitor, which binds with high affinity to the inactive state of KRAS and KRAS mutants.
BI-2865 is a cell penetrant, selective and potent pan-KRAS inhibitor, which binds with high affinity to the inactive state of KRAS and KRAS mutants. BI-2865 blocks nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants. It inhibits downstream signaling and growth in cancer cells harboring mutant KRAS. It does not bind to NRAS and HRAS.
BI-2865 is a cell penetrant, selective and potent pan-KRAS inhibitor, which binds with high affinity to the inactive state of KRAS and KRAS mutants. BI-2865 blocks nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants. It inhibits downstream signaling and growth in cancer cells harboring mutant KRAS. It does not bind to NRAS and HRAS.
| SKU | SIALUPENN-SML4151-5MG |
|---|---|
| Supplier Part Number | SML4151-5MG |
| UM | EA |
| UNSPSC | 12350000 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALUPENN |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 2937327-93-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |