Sigma-Aldrich Pepstatin A, Synthetic. 5 mg

Name: Sigma-Aldrich Pepstatin A, Synthetic. 5 mg
SKU: SIAL-516481-5MG
Price: 87.59 USD

List Price $87.59 Your Price $87.59

Sigma-Aldrich Pepstatin A, Synthetic. Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-516481-5MG

MFG.PART: 516481-5MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

description

Merck USA index - 14, 7147

Quality Level

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]20.0/D -90.0±5.0, c = 0.5 in methanol

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

DMSO: 1 mg/mL
methanol: 1 mg/mL

storage temp.

2-8°C

General description

A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 508437).

Effective concentration: 1.0 µM.

Biochem/physiol Actions

EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines

Primary Target
cathepsin D

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Isahara, K., et Al. 1999. Neuroscience91, 233.
Kanamori, S., et Al. 1998. Biochem. Biophys. Res. Commun.251, 204.
Szewczuk, Z., et Al. 1992. Int. J. Pept. Prot. Res.40, 233.
Carraway, R.E., et Al. 1991. Peptides12, 107.
Eid, M., et Al. 1981. Biochem. J.197, 465.
Umezawa, H., et Al. 1970. J. Antibiot.23, 259.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c