Sigma-Aldrich DPP IV Inhibitor. 1 mL

Dipeptidyl peptidase IV (DPP IV), a dimeric type II integral membrane glycoprotein, is a member of the family of prolyl-specific proteases. It is abundantly expressed in the epithelial and nonepithelial tissues. It is highly expressed in the kidney and the colon.[1]

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Dipeptidyl peptidase IV (DPP IV) controls insulin-stimulating hormones, glucagon-like peptide (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP). It′s a promising therapeutic target for type 2 diabetes (T2DM).[2] In addition to its catalytic action, DPP-4 also serves as a binding protein and a ligand of extracellular factors.[3] DPP-4 inhibition causes GLP-1 and GIP to have a prolonged activity, hence DPP-4 inhibitors help maintain glucose homeostasis. DPP IV inhibitors can improve glycemic control for a longer period when compared to early oral hypoglycemics.[4]

Upon arrival, store at 4°C. For long-term of more than 2 weeks, store at –20°C.