Sigma-Aldrich N-Acetyl-L-cysteine. 5 g

Name: Sigma-Aldrich N-Acetyl-L-cysteine. 5 g
SKU: SIAL-106425-5GM
Price: 119.50 USD

List Price $119.50 Your Price $119.50

Sigma-Aldrich N-Acetyl-L-cysteine. Mucolytic agent and thiol-based antioxidant that has a protective effect against oxygen free radicals in early septic shock.. 5 g - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-106425-5GM

MFG.PART: 106425-5GM

UNSPSC: 12352209

Manufacturer: Sigma-Aldrich

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Description

description

Merck USA index - 14, 88

Quality Level

200

assay

≥98% (titration)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

water: 50 mg/mL

anion traces

chloride (Cl^-): ≤0.04%
sulfate (SO₄^2-): ≤0.03%

cation traces

Fe: ≤20 ppm

General description

A mucolytic agent and thio-based antioxidant. Increases the cellular pool of free-radical scavengers. Inhibits HIV replication. Prevents apoptotic death of neuronal cells. Antidote for acetaminophen poisoning. May serve as a substrate for microsomal glutathione transferase. Induces apoptosis in human and rat smooth muscle cells.

Mucolytic agent and thiol-based antioxidant that has a protective effect against oxygen free radicals in early septic shock. Increases cellular pools of free-radical scavengers. Inhibitor of HIV replication. May serve as a substrate for microsomal glutathione transferase. Induces apoptosis in human and rat smooth muscle cells.

Application

Chlorpyrifos-induced suppression of the antioxidative defense system leads to cytotoxicity and genotoxicity in macrophages.: The study highlights the protective role of N-acetyl-L-cysteine against chlorpyrifos-induced oxidative damage in macrophages, emphasizing its importance in mitigating pesticide toxicity (Lu et Al., 2024).

N-Acetyl-L-Cysteine Attenuates Titanium Dioxide Nanoparticle (TiO2 NP)-Induced Autophagy in Male Germ Cells.: This research explores how N-acetyl-L-cysteine can mitigate the autophagic effects induced by titanium dioxide nanoparticles in male germ cells, suggesting its use in reproductive health (Shin et Al., 2024).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.

Other Notes

Ortolani, O., et Al. 2000. Am. J. Respir. Crit. Care Med. 161, 1907.
Tsai, J.C., et Al. 1996. J. Biol. Chem. 271, 3667.
Ferrari, g., et Al. 1995. J. Neurosci.15, 2857.
Weinander, R., et Al. 1994. J. Biol. Chem.269, 71.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c