Sigma-Aldrich Sotrastaurin. ≥98% (HPLC). 5 mg

Name: Sigma-Aldrich Sotrastaurin. ≥98% (HPLC). 5 mg
SKU: SIAL-SML3210-5MG
Price: 119.48 USD

List Price $119.48 Your Price $119.48

Sigma-Aldrich Sotrastaurin. ≥98% (HPLC). 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-SML3210-5MG

MFG.PART: SML3210-5MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

faint brown to dark red

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(NC1=O)C(C2=CNC3=C2C=CC=C3)=C1C4=C5C=CC=CC5=NC(N6CCN(CC6)C)=N4

InChI

1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)

InChI key

OAVGBZOFDPFGPJ-UHFFFAOYSA-N

Biochem/physiol Actions

Orally active, ATP site-targeting, potent and selective protein kinase C (PKC) inhibitor with in vivo immunosuppressive efficacy.

Sotrastaurin (AEB071) is an orally active, ATP site-targeting, potent and selective protein kinase C (PKC) inhibitor (Ki in nM/isoform = 0.95/α, 0.64/βI, 2.1/δ, 3.2/ε, 1.8/η and 2.2/θ; IC50 = 2.1/α, 2.0/βI, 1.3/δ, 6.2/ε, 6.1/η and 1.0/θ with 10 μM ATP). Sotrastaurin inhibits TCR/CD28-mediated T cell activation in cultures (IC50 = 54 nM by Jurkat IL-2 promoter reporter line) and exhibits in vivo immunosuppressive efficacy in rat models of local graft versus host (GvH) reaction and cardiac transplantation (10 and 30 mg/kg p.o. q.d. or b.i.d.).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c