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Sigma-Aldrich 5-pH-IAA. ≥97% (HPLC), auxin-inducible degron (AID) ligand, powder. 25 mg
List Price $407.16 Your Price $407.16
Sigma-Aldrich 5-pH-IAA. ≥97% (HPLC), auxin-inducible degron (AID) ligand, powder. 25 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART: SIAL-SML3574-25MG
MFG.PART: SML3574-25MG
UNSPSC: 10171502
Manufacturer: Sigma-Aldrich
Product Name
5-pH-IAA, ≥97% (HPLC)
Quality Level
100
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(CC1=CNC2=CC=C(C3=CC=CC=C3)C=C21)O
InChI key
ACCCWYHBDGKDKN-UHFFFAOYSA-N
Biochem/physiol Actions
5-pH-IAA is a bumped auxin-inducible degron (AID) ligand that induces Skp1-Cul1-F-box (SCF) E3 ligase complex-mediated ubiquitinaton of Arabidopsis IAA17-derived mini-AID (mAID) degron-fused target proteins in cells expressing a hole-modified Oryza sativa TIR1 (OsTIR1) mutant (F74G or F74A). Unlike the traditional AID system, 5-pH-IAA-based AID2 method shows no detectable leaky degradation, requires a 670-times lower ligand concentration, and achieves quicker degradation in cultures (0.2-5 μM) and in vivo (1-10 mg/kg via daily i.p. to mice xenografted with HCT116 CMV-OsTIR1(F74G) cells expressing mAID-tagged BRD4 or TOP2A).
Bumped AID2 system ligand that induces degradation of IAA17-derived mini-AID (mAID) degron-fused target proteins in cultures and in vivo.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
| SKU | SIAL-SML3574-25MG |
|---|---|
| Supplier Part Number | SML3574-25MG |
| UM | EA |
| UNSPSC | 10171502 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Energy Star | No |
| Green | No |
| Controlled | N |