We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Sigma-Aldrich Apocynin. ≥98% (GC), powder, NADPH oxidase inhibitor, Calbiochem®. 1 g
List Price $122.96 Your Price $122.96
Sigma-Aldrich Apocynin. ≥98% (GC), powder, NADPH oxidase inhibitor, Calbiochem®. 1 g - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART: SIAL-178385-1GM
MFG.PART: 178385-1GM
UNSPSC: 12352200
Manufacturer: Sigma-Aldrich
Product Name
Apocynin, A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.
Quality Level
100
description
Merck USA index - 14, 741
assay
≥98% (GC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white to brown
solubility
DMSO: 10 mg/mL
ethanol: 20 mg/mL
shipped in
ambient
General description
A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mm).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
NADPH oxidase
NADPH oxidase
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Abid, M.R., et Al. 2000. FEBS Lett.486, 252.
Muijsers, R.B., et Al. 2000. Br. J. Pharmacol.130, 932.
Lapperre, T.S., et Al. 1999. FEBS Lett.443, 235.
Supinski, g., et Al. 1999, J. Appl. Physiol.87, 776.
van der Goes, A., et Al. 1998. J. Neuroimmunol.92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.
Muijsers, R.B., et Al. 2000. Br. J. Pharmacol.130, 932.
Lapperre, T.S., et Al. 1999. FEBS Lett.443, 235.
Supinski, g., et Al. 1999, J. Appl. Physiol.87, 776.
van der Goes, A., et Al. 1998. J. Neuroimmunol.92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
pictograms
GHS07
signalword
Warning
hcodes
H315,H319,H335
pcodes
P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
| SKU | SIAL-178385-1GM |
|---|---|
| Supplier Part Number | 178385-1GM |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 10.000000 |
| Lead Time | 9 |
| Energy Star | No |
| Green | No |
| Controlled | N |