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Sigma-Aldrich Roflumilast. ≥98% (HPLC), powder, phosphodiesterase 4 PDE4 inhibitor. 10 mg
List Price $94.08 Your Price $94.08
Sigma-Aldrich Roflumilast. ≥98% (HPLC), powder, phosphodiesterase 4 PDE4 inhibitor. 10 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART: SIAL-SML1099-10MG
MFG.PART: SML1099-10MG
UNSPSC: 12352200
Manufacturer: Sigma-Aldrich
Product Name
Roflumilast, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
ClC1=CN=CC(Cl)=C1NC(C2=CC=C(OC(F)F)C(OCC3CC3)=C2)=O
InChI
1S/C17H14Cl2F2N2O3/C18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChI key
MNDBXUUTURYVHR-UHFFFAOYSA-N
Gene Information
human ... PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)
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Related Categories
Bioactive Small Molecule Inhibitors
Bioactive Small Molecules
Application
Roflumilast has been used to evaluate its effect on acute lung inflammation and chronic lung changes in models of cigarette exposure in mice.[1] It is also used to investigate its therapeutic potential to ameliorate primary blast-induced deficits in long-term potentiation (LTP).[2]
Biochem/physiol Actions
Roflumilast is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 0.8 nM. Roflumilast has anti-inflammatory properties and is used clinically to treat COPD.
Roflumilast is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
pictograms
GHS07
signalword
Warning
hcodes
H315,H319,H335
pcodes
P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
| SKU | SIAL-SML1099-10MG |
|---|---|
| Supplier Part Number | SML1099-10MG |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Sigma-Aldrich |
| Temperature | -20C |
| Refrigerated-Frozen | Y |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 10.000000 |
| Lead Time | 9 |
| CAS Number | 162401-32-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |