Sigma-Aldrich Hypoxanthine. ≥99.0%, synthetic (organic), powder. 1 g

Name: Sigma-Aldrich Hypoxanthine. ≥99.0%, synthetic (organic), powder. 1 g
SKU: SIAL-H9377-1G
Price: 84.22 USD

List Price $84.22 Your Price $84.22

Sigma-Aldrich Hypoxanthine. ≥99.0%, synthetic (organic), powder. 1 g - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-H9377-1G

MFG.PART: H9377-1G

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

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Description

Product Name

Hypoxanthine, ≥99.0%

biological source

synthetic (organic)

Quality Level

300

assay

≥99.0%

form

powder

mp

>300 °C (lit.)

solubility

formic acid: water (2:1): 50 mg/mL, clear to slightly hazy, colorless to yellow

SMILES string

O=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

Inchi Key

FDGQSTZJBFJUBT-UHFFFAOYSA-N

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Application

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.

Hypoxanthine has been used:

to gavage mice and to evaluate the activity of xanthine oxidase (XO) in pasteurized whole milk in vivo in potassium oxonate (PO) -induced mouse model of hyperuricemia[1]
as a supplement in Iscove′s modified Dulbecco′s medium (IMDM) medium to cultivate in-vitro cell line (EL-1 cells)[2]
as a pure standard for the quantification of hypoxanthine in vitreous fluid sample using high-performance liquid chromatography-ultra-violet (HPLC-UV) for the estimation of post-mortem interval[3]

Biochem/physiol Actions

Hypoxanthine acts as an intermediate in purine metabolism. It elicits a vital role as a 5′-base of the anticodon in a few transfer-RNAs. Though similar to guanine (Gua), it is devoid of the exocyclic amino group at C(2) position.[4] It may be used as a substrate to study the specificity and kinetics of hypoxanthine-guanine phosphoribosyl transferases.[5]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c