Sigma-Aldrich Bindarit. ≥98% (HPLC). 5 mg

Name: Sigma-Aldrich Bindarit. ≥98% (HPLC). 5 mg
SKU: SIAL-SML2910-5MG
Price: 120.64 USD

List Price $120.64 Your Price $120.64

Sigma-Aldrich Bindarit. ≥98% (HPLC). 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-SML2910-5MG

MFG.PART: SML2910-5MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[n]2(nc(c3c2cccc3)COC(C)(C)C(=O)O)Cc1ccccc1

InChI

1S/C19H20N2O3/c1-19(2,18(22)23)24-13-16-15-10-6-7-11-17(15)21(20-16)12-14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3,(H,22,23)

InChI key

MTHORRSSURHQPZ-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Biochem/physiol Actions

Bindarit is an indazolic derivative with anti-inflammatory efficacy in vitro (150-300 μM) and in animal disease models in vivo (100 mg/kg ip, 50 mg/kg PO, or 0.5% in chow; rats & mice). Bindarit selectively inhibits LPS-induced CCL2/MCP-1, CCL7/MCP-3, CCL8/MCP-2 chemokines over CCL3/MIP-1α and IL-8/CXCL8 in human monocytes, while blocking CCL2, but not CCL7 or CCL8, induction in HUVECs, and preventing LPS-induced CCL2 & IL-12β/p40 by inhibiting NFκB activation in murine macrophages (BMDM & Raw 264.7). Bindarit is also reported to exhibit non-competitive inhibiory potency against human monocarboxylate transporter MCT4 (K_i = 30.2 μM) over MCT1 (<40% inhibition at 500 μM).

NFκB activation, CCL2 (MCP1) & IL-12β/p40 induction blocker with anti-inflammation efficacy in vivo. Selectively inhibits monocarboxylate transporter MCT4 over MCT1.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c