Sigma-Aldrich β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate. ≥95.0% (HPLC). 100 mg

Name: Sigma-Aldrich β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate. ≥95.0% (HPLC). 100 mg
SKU: SIAL-43420-100MG
Price: 66.94 USD

List Price $66.94 Your Price $66.94

Sigma-Aldrich β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate. ≥95.0% (HPLC). 100 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-43420-100MG

MFG.PART: 43420-100MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

assay

≥95.0% (HPLC)

form

powder

cation traces

Ca: ≤200 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
CR: ≤5 mg/kg
Cu: ≤20 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
mg: ≤200 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

absorbance ratio

A_260/340 nm ≤2.40

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O

InChI

1S/C21H29N7O14P2.2Na.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;;1H2/q;2*+1;/p-2/t10-,11-,13-,14-,15-,16-,20-,21-;;;/m1.../s1

InChI key

FWBNCIFELNNJCX-UHOVGGJYSA-L

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Application

As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Nicotinamide adenine dinucleotide (NAD) and NADH form a redox pair. NAD/NADH is a coenzyme that supports redox reactions via the transport of electrons in a vast array of applications. NAD is also involved in post-translational (Poly(ADP-ribose) polymerization) modifications of proteins.

Biochem/physiol Actions

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD⁺/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Packaging

Packaged by solid weight.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c