Sigma-Aldrich Nω-Nitro-L-arginine methyl ester hydrochloride. ≥97% (TLC), powder, nitric oxide production inhibitor. 5 g

Name: Sigma-Aldrich Nω-Nitro-L-arginine methyl ester hydrochloride. ≥97% (TLC), powder, nitric oxide production inhibitor. 5 g
SKU: SIAL-N5751-5G
Price: 182.12 USD

List Price $182.12 Your Price $182.12

Sigma-Aldrich Nω-Nitro-L-arginine methyl ester hydrochloride. ≥97% (TLC), powder, nitric oxide production inhibitor. 5 g - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-N5751-5G

MFG.PART: N5751-5G

UNSPSC: 41116113

Manufacturer: Sigma-Aldrich

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Description

Product Name

N_ω-Nitro-L-arginine methyl ester hydrochloride, ≥97% (TLC), powder

biological source

synthetic

assay

≥97% (TLC)

form

powder

color

white to off-white

mp

132 °C

solubility

H₂O: 50 mg/mL

storage temp.

−20°C

SMILES string

Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O

InChI

1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1

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General description

Nω-Nitro-L-argininemethyl ester hydrochloride or L -NAME HCl, ananalog of arginine, inhibits NO production. It has multiple effects on thevascular system. Inhibits relaxation induced by acetylcholine and induces anincrease in arterial blood pressure. Abolishes lecithinized superoxidedismutase induced vasodilation when used to pretreat aortic ring preparationsof mice. Induces leukocyte adhesion and increases microvascular fluid andprotein fluxes and permeability. It has also been used in many studies oflearning and memory.

Application

Nω-Nitro-L-arginine methyl ester hydrochloride has been used:

to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons[1]
to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin[2]
to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells[3]
to study its effect on the levels of arginine vasopressin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat[4]

Biochem/physiol Actions

Arginine analog that inhibits NO production.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c