Sigma-Aldrich W-7, Hydrochloride. 10 mg

Name: Sigma-Aldrich W-7, Hydrochloride. 10 mg
SKU: SIAL-681629-10MG
Price: 184.44 USD

List Price $184.44 Your Price $184.44

Sigma-Aldrich W-7, Hydrochloride. 10 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-681629-10MG

MFG.PART: 681629-10MG

UNSPSC: 12352202

Manufacturer: Sigma-Aldrich

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Description

Quality Level

100

description

RTECS - QK0786000

assay

≥98% (TLC)

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

off-white

solubility

DMSO: 5 mg/mL
DMF: soluble
warm ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 µM) and myosin light chain kinase (IC₅₀ = 51 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Myosin light chain kinase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 51 µM inhibiting myosin light chain kinase; 28 µM inhibiting Ca2+-calmodulin-dependent phosphodiesterase

Other Notes

Caulfield, M.P., et Al. 1991. Neurosci. Lett.125, 57.
Asano, M. 1989. J. Pharmacol. Exp. Ther.251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem.96, 1721.
Tanaka, T., et Al. 1983. Pharmacol.26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c