Sigma-Aldrich Amitriptyline hydrochloride. ≥98% (TLC), norepinephrine and serotonin transporter inhibitor, powder. 100 g

Name: Sigma-Aldrich Amitriptyline hydrochloride. ≥98% (TLC), norepinephrine and serotonin transporter inhibitor, powder. 100 g
SKU: SIAL-A8404-100G
Price: 367.72 USD

List Price $367.72 Your Price $367.72

Sigma-Aldrich Amitriptyline hydrochloride. ≥98% (TLC), norepinephrine and serotonin transporter inhibitor, powder. 100 g - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-A8404-100G

MFG.PART: A8404-100G

UNSPSC: 41116107

Manufacturer: Sigma-Aldrich

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Description

Product Name

Amitriptyline hydrochloride, ≥98% (TLC), powder

assay

≥98% (TLC)

form

powder

color

white to off-white

solubility

H₂O: soluble
ethanol: soluble

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChI key

KFYRPLNVJVHZGT-UHFFFAOYSA-N

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Amitriptyline hydrochloride has been used:

as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice[1]
as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood[2]
as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse[3]

Biochem/physiol Actions

Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia.[4] It possesses antihistaminic, anticholinergic, and antiserotonimic properties.[5] Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.[4]

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Features and Benefits

Shelf-life of the powder is at least three years.

pictograms

GHS06,GHS08,GHS09

signalword

Danger

hcodes

H301,H319,H361d,H410

pcodes

P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c