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Sigma-Aldrich Carbonyl Cyanide M-Chlorophenylhydrazone. ≥97% (TLC), powder, mitophagy inducer. 250 mg
List Price $128.76 Your Price $128.76
Sigma-Aldrich Carbonyl Cyanide M-Chlorophenylhydrazone. ≥97% (TLC), powder, mitophagy inducer. 250 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART: SIAL-C2759-250MG
MFG.PART: C2759-250MG
UNSPSC: 12352200
Manufacturer: Sigma-Aldrich
Product Name
Carbonyl cyanide 3-chlorophenylhydrazone, ≥97% (TLC), powder
assay
≥97% (TLC)
form
powder
color
yellow to orange
solubility
DMSO: 100 mm
storage temp.
−20°C
SMILES string
Clc1cccc(N\N=C(\C#N)C#N)c1
InChI
1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H
Inchi Key
UGTJLJZQQFGTJD-UHFFFAOYSA-N
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Related Categories
Bioactive Small Molecule Inhibitors
Bioactive Small Molecules
Application
Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) has been used:
- in the inhibition of efflux pump in clinical Pseudomonas aeruginosa[1]
- to inhibit oxidative phosphorylation activity of mitochondria in human Beas-2B bronchial epithelial cells[2]
- to prepare carbonyl cyanide M-chlorophenylhydrazone solution for oxidative and mitochondrial stress assay and mitophagy induction in Caenorhabditis elegans[3]
Biochem/physiol Actions
Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) induces mitophagy in mammalian cells.[3] CCCP suppresses the expression of few electron transport chain (ETC) proteins.[2] Protonophore (H+ ionophore) and uncoupler of oxidative phosphorylation in mitochondria. Shown to have a number of effects on cellular calcium. Inhibits secretion of hepatic lipase and partially inhibits the pH gradient-activated Cl- uptake and Cl-/Cl- exchange activities in brush-border membrane vesicles.
Other Notes
2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
pictograms
GHS06
signalword
Danger
hcodes
H301 + H311 + H331,H315,H319,H335
pcodes
P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
PPE
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
| SKU | SIAL-C2759-250MG |
|---|---|
| Supplier Part Number | C2759-250MG |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Sigma-Aldrich |
| Temperature | -20C |
| Refrigerated-Frozen | Y |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 10.000000 |
| Lead Time | 9 |
| CAS Number | 555-60-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |