Sigma-Aldrich Chlorzoxazone. 100 g

Name: Sigma-Aldrich Chlorzoxazone. 100 g
SKU: SIAL-C4397-100G
Price: 399.04 USD

List Price $399.04 Your Price $399.04

Sigma-Aldrich Chlorzoxazone. 100 g - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-C4397-100G

MFG.PART: C4397-100G

UNSPSC: 51000000

Manufacturer: Sigma-Aldrich

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Description

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

191-192 °C (lit.)

solubility

DMSO: 50 mg/mL, clear

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

Clc1ccc2OC(=O)Nc2c1

InChI

1S/C7H4ClNO2/C8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)

InChI key

TZFWDZFKRBELIQ-UHFFFAOYSA-N

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Application

Chlorzoxazone may be used:

as a calcium-activated potassium (K_Ca) channel activator in patch-clamp electrophysiology to test its effect on dendritic hyperexcitability[1]
as a substrate for cytochrome P450 2E1 (CYP2E1) enzyme in cultured human hepatocytes[2]
as a benzimidazolone compound to test its effect on epithelial sodium (Na⁺) transport[3]

Biochem/physiol Actions

Chlorzoxazone inhibits the multisynaptic reflex arcs primarily in the spinal cord and brain subcortical areas.[4] It is an activator of calcium activated potassium channels and may contribute to the aortic artery relaxation in mice.[5] Chlorzoxazone also activates the calcium-activated potassium (K_Ca) channel and small conductance calcium-activated potassium channels (SK).[1] It is metabolized by cytochrome P450 2E1 (CYP2E1) and serves as a probe for monitoring this enzyme function.[6]

Chlorzoxazone is a skeletal muscle relaxant.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c