Sigma-Aldrich 6-Hydroxydopamine hydrochloride. ≥97% (titration), powder, neurotoxin. 100 mg

6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death.[1][2] 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.[2]

6-hydroxydopamine hydrochloride has been used:

• to induce Parkinson′s disease (PD) in rats[1]
• to analyse cytotoxic effect of 6-OHDA on PC12 cell line[3]
• to induce noradrenergic (NA) neuron deletion from the locus-coeruleus[2]

Neurotoxin that destroys catecholaminergic terminals.

Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.

Solutions should be freshly prepared and protected from exposure to light. Solutions turn red as it oxidizes.

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Hygroscopic