Sigma-Aldrich Leflunomide. ≥98% (TLC), T cell proliferation inhibitor, powder. 100 mg

Name: Sigma-Aldrich Leflunomide. ≥98% (TLC), T cell proliferation inhibitor, powder. 100 mg
SKU: SIAL-L5025-100MG
Price: 450.08 USD

List Price $450.08 Your Price $450.08

Sigma-Aldrich Leflunomide. ≥98% (TLC), T cell proliferation inhibitor, powder. 100 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-L5025-100MG

MFG.PART: L5025-100MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

Leflunomide, Immunosuppressant

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

166.5 °C

solubility

methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

mode of action

enzyme | inhibits

storage temp.

2-8°C

SMILES string

Cc1oncc1C(=O)Nc2ccc(cc2)C(F)(F)F

InChI

1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation[1] and treatment of rheumatoid arthritis[2] and other autoimmune diseases.

Biochem/physiol Actions

Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.

pictograms

GHS06

signalword

Danger

hcodes

H301,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c