Sigma-Aldrich Latrunculin A. From sea sponge, ≥85% (HPLC), Inhibitor of actin assembly and polymerization, waxy solid. 100 μg

Name: Sigma-Aldrich Latrunculin A. From sea sponge, ≥85% (HPLC), Inhibitor of actin assembly and polymerization, waxy solid. 100 μg
SKU: SIAL-L5163-100UG
Price: 470.96 USD

List Price $470.96 Your Price $470.96

Sigma-Aldrich Latrunculin A. From sea sponge, ≥85% (HPLC), Inhibitor of actin assembly and polymerization, waxy solid. 100 μg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-L5163-100UG

MFG.PART: L5163-100UG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

Latrunculin A, from sea sponge, ≥85% (HPLC), waxy solid

biological source

sea sponge

Quality Level

200

assay

≥85% (HPLC)

form

waxy solid

mol wt

421.6

solubility

DMSO: soluble
ethanol: soluble

storage temp.

−20°C

SMILES string

C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CC\C=C\C=C1

InChI

1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

General description

Latrunculin A, a toxin extracted from the red sea sponge Latrunculia magnifica. It participates in vitro in the morphological alteration of the polymerization of pure actin.[1] It forms a complex by binding with the nucleotide cleft of actin for actin filaments elongation.[2]

Application

Latrunculin A has been used as medium supplementation for A549 cells to determine the internalization mechanism of CAV9 in A549 human lung carcinoma cells.[3]

Biochem/physiol Actions

Latrunculin A inhibits actin polymerization by a different mechanism than cytochalasins. Latrunculin A disrupts microfilament-mediated processes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c