Sigma-Aldrich BMS 493. ≥98% (HPLC), powder, pan-RAR inverse agonist. 25 mg

Name: Sigma-Aldrich BMS 493. ≥98% (HPLC), powder, pan-RAR inverse agonist. 25 mg
SKU: SIAL-B6688-25MG
Price: 1038.20 USD

List Price $1,038.20 Your Price $1,038.20

Sigma-Aldrich BMS 493. ≥98% (HPLC), powder, pan-RAR inverse agonist. 25 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-B6688-25MG

MFG.PART: B6688-25MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

BMS 493, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

light yellow to yellow

solubility

DMSO: ≥20 mg/mL

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

CC1(C)CC=C(C#Cc2ccccc2)c3cc(\C=C\c4ccc(cc4)C(O)=O)ccc13

InChI

1S/C29H24O2/c1-29(2)19-18-24(14-10-21-6-4-3-5-7-21)26-20-23(13-17-27(26)29)9-8-22-11-15-25(16-12-22)28(30)31/h3-9,11-13,15-18,20H,19H2,1-2H3,(H,30,31)/b9-8+

InChI key

YCADIXLLWMXYKW-CMDGGOBGSA-N

Related Categories

Bioactive Small Molecule Agonists

Bioactive Small Molecules

General description

BMS 493 inhibits the formation of neuritic processes and plasmenyethanolamine -phospholipase A2 (PLA2) activity.[1]

Application

BMS 493 has been used:

as an inhibitor for the dietary and pharmacologic manipulation of retinoic acid (RA) activity in vivo and in vitro[2]
for human induced pluripotent stem cells (iPSCs) culture and ventricular cardiomyocytes (VCMs) differentiation[3]
to inhibit retinoic acid (RA) signaling in explants[4][5]
as a retinoic acid receptor (RAR) inhibitor for the induction of synaptonemal complex protein 3 (SCP3) and ATP-dependent RNA helicase (DDX4) in primordial germ cells (PGCs)[6]

Biochem/physiol Actions

BMS 493 is an inverse pan-RAR agonist.

BMS 493 is an inverse pan-RAR agonist. Retinoic acid receptors (RARs) are ligand-dependent transcription factors that control a number of physiological processes. RARs exert their functions by regulating gene networks controlling cell growth, differentiation, survival, and death.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c