Sigma-Aldrich DL-α-Difluoromethylornithine hydrochloride hydrate. ≥97% (NMR), solid, polyamine biosynthesis inhibitor. 25 mg

Name: Sigma-Aldrich DL-α-Difluoromethylornithine hydrochloride hydrate. ≥97% (NMR), solid, polyamine biosynthesis inhibitor. 25 mg
SKU: SIAL-D193-25MG
Price: 308.56 USD

List Price $308.56 Your Price $308.56

Sigma-Aldrich DL-α-Difluoromethylornithine hydrochloride hydrate. ≥97% (NMR), solid, polyamine biosynthesis inhibitor. 25 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-D193-25MG

MFG.PART: D193-25MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

DL-α-Difluoromethylornithine hydrochloride hydrate, solid, ≥97% (NMR)

assay

≥97% (NMR)

form

solid

color

white

solubility

DMSO: >10 mg/mL
H₂O: >10 mg/mL

SMILES string

O.Cl.NCCCC(N)(C(F)F)C(O)=O

InChI

1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2

Inchi Key

FJPAMFNRCFEGSD-UHFFFAOYSA-N

Gene Information

human ... ODC1(4953)

General description

Difluoromethylornithine is a fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer.[1] It exhibits cytostatic effects on mammalian cells and tissues.[2]

Application

DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation.[3] It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.[4]

Biochem/physiol Actions

Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.

Inhibits polyamine biosynthesis by selective, irreversible inhibition of ornithine decarboxylase. Chemoprotective agent that blocks angiogenesis.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c