Sigma-Aldrich β-Nicotinamide adenine dinucleotide phosphate hydrate. 100 mg

Name: Sigma-Aldrich β-Nicotinamide adenine dinucleotide phosphate hydrate. 100 mg
SKU: SIAL-N5755-100MG
Price: 226.20 USD

List Price $226.20 Your Price $226.20

Sigma-Aldrich β-Nicotinamide adenine dinucleotide phosphate hydrate. 100 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-N5755-100MG

MFG.PART: N5755-100MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

biological source

chicken liver

assay

≥95% (HPLC)
≥95% (spectrophotometric assay)

form

powder

solubility

H₂O: soluble 50 mg/mL, clear, colorless to faintly yellow

cation traces

sodium and potassium: ≤0.04%

storage temp.

−20°C

SMILES string

O.NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(O)=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O

InChI

1S/C21H28N7O17P3.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);1H2/t10-,11-,13-,14-,15-,16-,20-,21-;/m1./s1

InChI key

ZKJOXOJMGXFSPF-QYZPTAICSA-N

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Application

β-Nicotinamide adenine dinucleotide phosphate hydrate is suitable for use in:

the measurement of Glucose-6-phosphate dehydrogenase activity[1]
the Cytochrome P450 3A4 assay as a part of NADPH-regenerating system[2]
the Cytochrome P450 2D6 assay as a part of NADPH-regenerating system[3]
the determination of Glucose-6-phosphate content[4]

Biochem/physiol Actions

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation.[5] The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).[6]

Electron acceptor

Other Notes

Packaged based on solid weight.

This is a common form of NADP.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c