Sigma-Aldrich Oxytocin. 500 I.U.

Name: Sigma-Aldrich Oxytocin. 500 I.U.
SKU: SIAL-O3251-500IU
Price: 79.58 USD

List Price $79.58 Your Price $79.58

Sigma-Aldrich Oxytocin. 500 I.U. - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-O3251-500IU

MFG.PART: O3251-500IU

UNSPSC: 51180000

Manufacturer: Sigma-Aldrich

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Description

biological source

synthetic (organic)

sterility

non-sterile

assay

≥97% (HPLC)

form

lyophilized powder

UniProt accession no.

P01178
P30559
P70536

shipped in

ambient

storage temp.

2-8°C

SMILES string

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

InChI

1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1

Inchi Key

XNOPRXBHLZRZKH-DSZYJQQASA-N

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Related Categories

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Hormones

Molecular Biology & Functional Genomics

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

General description

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13.[1][2] It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.[1]

Application

Oxytocin has been used in experimental study to induce uterine contractions in rats.[3] It has been used in comet assay to determine the number of cells with DNA damage.[4]

Biochem/physiol Actions

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation.[1] OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation.[2] Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity.[5] OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings.[6] Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).[7]

Stimulates uterine contraction and lactation; increases Na⁺ excretion; stimulates myometrial GTPase and phospholipase C.

Physical form

Supplied as a powder with a peptide content of ≥ 75%

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c