Sigma-Aldrich L-Cysteine S-sulfate. ≥98% (TLC), suitable for ligand binding assays. 25 mg

L-Cysteine S-sulfate (LCSS) is used as an NMDA glutamatergic receptor agonist.[1] It serves as a substrate for cystine lyase(s).
Cysteine is one of the functional amino acids that are associated with growth, reproduction, maintenance and immunity. Cysteine is a source of disulfide linkage in protein and is associated with sulfur transport. At physiological pH, cysteine undergoes rapid oxidation to form cystine.[2] Reduced availability of cysteine or cystine, influences leukocyte metabolism.[3] L-Cysteine serves as a precursor for the rate limiting step in glutathione synthesis that occurs in neurons. It donates inorganic sulfate for detoxification reactions. Therefore, L-cysteine might be associated with neuroprotection. It is found to obstruct the entry of heavy metal ions across the blood-brain barrier into the brain. Increased levels of L-cysteine might lead to neurotoxicity.[4]