Sigma-Aldrich Manumycin A. from Streptomyces parvulus, ≥97% (HPLC), Ras farnesyltransferase inhibitor, powder. 5 mg

Name: Sigma-Aldrich Manumycin A. from Streptomyces parvulus, ≥97% (HPLC), Ras farnesyltransferase inhibitor, powder. 5 mg
SKU: SIAL-M6418-5MG
Price: 997.60 USD

List Price $997.60 Your Price $997.60

Sigma-Aldrich Manumycin A. from Streptomyces parvulus, ≥97% (HPLC), Ras farnesyltransferase inhibitor, powder. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-M6418-5MG

MFG.PART: M6418-5MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

Manumycin A from Streptomyces parvulus,

assay

≥97% (HPLC)

Quality Level

200

form

powder

solubility

methanol: 9.80-10.20 mg/mL, clear, yellow to very deep yellow

storage temp.

2-8°C

SMILES string

CCCC[C@@H](C)\C=C(C)\C=C(/C)C(=O)NC1=C[C@@](O)(\C=C\C=C\C=C\C(=O)NC2=C(O)CCC2=O)[C@@H]3O[C@H]3C1=O

InChI

1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28?,29-,31+/m1/s1

InChI key

TWWQHCKLTXDWBD-YCWSEAROSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Manumycin A from Streptomyces parvulus has been used to inhibit IκB kinase (IKK)b−nuclear κ-B essential modulator (NEMO) interaction in the homogeneous time-resolved fluorescence (HTRF)-based binding assay.[1]

Biochem/physiol Actions

Manumycin A is a natural monomeric epoxyquinoid. It has an ability to inhibit tumor necrosis factor (TNF) induced IκB kinase (IKK) activity in various cell types. In addition, manumycin A exhibits anti-tumor property by inhibiting farnesylation of oncogenic Ras.[2]

Potent inhibitor of Ras farnesyltransferase.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c