Sigma-Aldrich GW405833 hydrochloride. ≥98% (HPLC), Selective cannabinoid CB2 receptor agonist, solid. 5 mg

Name: Sigma-Aldrich GW405833 hydrochloride. ≥98% (HPLC), Selective cannabinoid CB2 receptor agonist, solid. 5 mg
SKU: SIAL-G1421-5MG
Price: 165.88 USD

List Price $165.88 Your Price $165.88

Sigma-Aldrich GW405833 hydrochloride. ≥98% (HPLC), Selective cannabinoid CB2 receptor agonist, solid. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-G1421-5MG

MFG.PART: G1421-5MG

UNSPSC: 12352202

Manufacturer: Sigma-Aldrich

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Description

Product Name

GW405833 hydrochloride, ≥98% (HPLC), solid

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

storage condition

desiccated

color

white to pink

solubility

DMSO: soluble >10 mg/mL
H₂O: insoluble <2 mg/mL

storage temp.

2-8°C

SMILES string

Cl.COc1ccc2n(c(C)c(CCN3CCOCC3)c2c1)C(=O)c4cccc(Cl)c4Cl

InChI

1S/C23H24Cl2N2O3.ClH/c1-15-17(8-9-26-10-12-30-13-11-26)19-14-16(29-2)6-7-21(19)27(15)23(28)18-4-3-5-20(24)22(18)25;/h3-7,14H,8-13H2,1-2H3;1H

Application

GW405833 hydrochloride has been used as a lysosomal transient receptor potential mucolipin 1 (TRPML1) specific inhibitor to validate if TRPML1 mediates tau release in neurons and also to verify if it mediates the release of lysosomal tau.[1] It has also been used as a TRPML channel blocker to study the effect of mucolipin transient receptor potential cation channel 3 (MCOLN3/TRPML3) function and trafficking on autophagy in HeLa cells.[2]

Biochem/physiol Actions

GW405833 hydrochloride, also known as mL-SI1, is a cell-permeable[2] lysosomal transient receptor potential cation channel, mucolipin subfamily (TRPML) blocker.[3]

GW405833 is a selective cannabanoid CB2 receptor agonist; analgesic. GW405833 binds with high affinity at both human and rat CB2 receptors (Ki′s 3.9 and 3.6 nM); acts as a partial agonist (50% inhibition of forskolin-stimulated cAMP formation compared to full agonist CP55,940). GW405833 has potent analgesic activity in rat models of inflammatory, neuropathic and incisional pain; devoid of CNS effects common with CB1 agonists.

Selective cannabinoid CB2 receptor agonist; analgesic.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301,H413

pcodes

P264 - P270 - P273 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c