Sigma-Aldrich ICRF-193. synthetic (organic), ≥95%, topoisomerase II inhibitor, solid,powder or flakes. 1 mg

Name: Sigma-Aldrich ICRF-193. synthetic (organic), ≥95%, topoisomerase II inhibitor, solid,powder or flakes. 1 mg
SKU: SIAL-I4659-1MG
Price: 424.56 USD

List Price $424.56 Your Price $424.56

Sigma-Aldrich ICRF-193. synthetic (organic), ≥95%, topoisomerase II inhibitor, solid,powder or flakes. 1 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-I4659-1MG

MFG.PART: I4659-1MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Description

Product Name

ICRF-193, apoptosis inducer, arabinosidase substrate

biological source

synthetic (organic)

assay

≥95%

form

powder or flakes
solid

solubility

DMSO: 4 mg/mL

storage temp.

−20°C

SMILES string

C[C@@H]([C@@H](C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

InChI

1S/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20)/t7-,8+

InChI key

OBYGAPWKTPDTAS-OCAPTIKFSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

General description

ICRF-193 is a bisdiopiperazine derivative.[1] It inhibits topoisomerase II by forming a non-cleavable complex.[2]

Application

ICRF-193 has been used as a topoisomerase II (TOP2) inhibitor to treat mouse oocytes to investigate the role of TOP2 in meiosis.[3]

Biochem/physiol Actions

ICRF-193 helps in the enhancement of cell cycle without chromosome segregation.[2] It is considered as an important drug for chemo-differentiation therapy against acute promyelocytic leukemia (APL). ICRF-193 serves as an inducer of differentiation between anticancer drugs.[1]

ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.[4] Induces apoptosis in several cell lines including K562 and Molt-4 cells.[5]^,[4] ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α[6], and may in addition cause DNA strand breaks.[7]

pictograms

GHS06

signalword

Danger

hcodes

H301,H317

pcodes

P280 - P301 + P310 + P330 - P302 + P352

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c