Sigma-Aldrich Monastrol. ≥98% (HPLC), Mitosis inhibitor, solid. 5 mg

Name: Sigma-Aldrich Monastrol. ≥98% (HPLC), Mitosis inhibitor, solid. 5 mg
SKU: SIAL-M8515-5MG
Price: 598.56 USD

List Price $598.56 Your Price $598.56

Sigma-Aldrich Monastrol. ≥98% (HPLC), Mitosis inhibitor, solid. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-M8515-5MG

MFG.PART: M8515-5MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

Monastrol, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

white to off-white

mp

185-185.9 °C (lit.)

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

CCOC(=O)C1=C(C)NC(=S)NC1c2cccc(O)c2

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Monastrol has been used:

to treat MDA-MB-231 cells as a non-microtubule-targeting agent[1]
as a antineoplastic agent, to treat mouse myeloma cell line SP 2/0, to induce apoptosis and to elucidate the role of metabotropic glutamate receptor 3 (Grm3) in apoptosis[2]
as an inhibitor of pteridine reductase in GFP-transfected promastigotes infected macrophages for flow cytometer-based growth inhibition assay and to evaluate anti-leishmanial activity of Leishmania donovani hamster model in vivo[3]

Biochem/physiol Actions

Monastrol is a potent, cell-permeant inhibitor of mitosis. Monastrol arrested cells are characterized by monopolar spindles. This phenotype is induced through specific disruption of mitotic molecular motor kinesin Eg5 with IC₅₀ at 14 μM. No effect on other motor proteins and tubulin.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Packaged under inert gas.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c