Sigma-Aldrich PD184352. ≥98% (HPLC). 5 mg

Name: Sigma-Aldrich PD184352. ≥98% (HPLC). 5 mg
SKU: SIAL-PZ0181-5MG
Price: 165.88 USD

List Price $165.88 Your Price $165.88

Sigma-Aldrich PD184352. ≥98% (HPLC). 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-PZ0181-5MG

MFG.PART: PZ0181-5MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥30 mg/mL

storage temp.

room temp

SMILES string

Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F

InChI

1S/C17H14ClF2IN2O2/C18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)

InChI key

GFMMXOIFOQCCGU-UHFFFAOYSA-N

Gene Information

human ... MAP2K1(5604), MAP2K2(5605)

Biochem/physiol Actions

PD184352 (CI-1040) is a highly selective MEK (MKK1; MAPK kinase) inhibitor.

PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS09

signalword

Warning

hcodes

H400

pcodes

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c