Sigma-Aldrich mL-7 Hydrochloride. >98% (TLC), protein kinase A and C inhibitor, solid. 1 mg

Name: Sigma-Aldrich mL-7 Hydrochloride. >98% (TLC), protein kinase A and C inhibitor, solid. 1 mg
SKU: SIAL-475880-1MG
Price: 251.72 USD

List Price $251.72 Your Price $251.72

Sigma-Aldrich mL-7 Hydrochloride. >98% (TLC), protein kinase A and C inhibitor, solid. 1 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-475880-1MG

MFG.PART: 475880-1MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

mL-7, Hydrochloride, A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (K_i = 300 nM).

Quality Level

100

assay

>98% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

50% ethanol: 4.5 mg/mL
DMSO: 4.5 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (K_i = 300 nM). Inhibits protein kinase A (K_i = 21 µM)and protein kinase C (K_i = 42 µM) at much higher concentrations.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Myosin light chain kinase (Mlck)

Product competes with ATP.

Reversible: yes

Target K_i: 300 nM against myosin light chain kinase

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Further dilute with aqueous buffer just prior to use.

Other Notes

Krarup, T., et Al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et Al. 1987. J. Biol. Chem.262, 7796.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c