Sigma-Aldrich 7-Methylguanosine 5′-triphosphate sodium salt. ≥85% (HPLC), natural (inorganic), powder. 5 mg

Name: Sigma-Aldrich 7-Methylguanosine 5′-triphosphate sodium salt. ≥85% (HPLC), natural (inorganic), powder. 5 mg
SKU: SIAL-M6133-5MG
Price: 262.16 USD

List Price $262.16 Your Price $262.16

Sigma-Aldrich 7-Methylguanosine 5′-triphosphate sodium salt. ≥85% (HPLC), natural (inorganic), powder. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-M6133-5MG

MFG.PART: M6133-5MG

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

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Description

Product Name

7-Methylguanosine 5′-triphosphate sodium salt, ≥85% (HPLC)

biological source

natural (inorganic)

assay

≥85% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to faint yellow or tan

storage temp.

−20°C

SMILES string

[Na+].C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3N=C(N)NC([O-])c13

InChI

1S/C11H20N5O14P3.Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22;/h3-4,6-7,9-10,17-18H,2H2,1H3,(H,23,24)(H,25,26)(H3,12,13,14)(H2,20,21,22);/q;+1/p-1/t4-,6-,7-,9?,10-;/m1./s1

InChI key

FSMRTZAMTMQMEF-OCMBMSOASA-M

Related Categories

Biochemicals

Chemistry & Biochemicals

Nucleosides and Nucleotides

Phosphates

General description

7-Methylguanosine 5′-triphosphate is a mRNA cap structural analog.[1]

Application

7-Methylguanosine 5′-triphosphate (m7GTP) is use to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP may be used to create affinity media for capture and purification of molecules such as eukaryotic initiation factor eIF4E.

7-Methylguanosine 5′-triphosphate sodium salt has been used to test its affinity towards Poly(A)-specific ribonuclease (PARN) polypeptides using fluorescence titrations.[2] It has also been used in crystallization along with gemin5 fragment (G5N)[3] and DM15 region of human La-related 15 protein 1 ( LARP1).[4]

Biochem/physiol Actions

7-Methylguanosine 5′-triphosphate (m7GTP) inhibits in vitro protein synthesis by binding to translation initiation complexes.[1] m7GTP is useful to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis.[5] m7GTP has a high affinity for eukaryotic initiation factor eIF4E[1] and may be used to create affinity media for their capture and purification.[6]

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c