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Sigma-Aldrich N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin. ≥90% (HPLC), Chymotrypsin substrate, powder. 5 mg
List Price $237.80 Your Price $237.80
Sigma-Aldrich N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin. ≥90% (HPLC), Chymotrypsin substrate, powder. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART: SIAL-S6510-5MG
MFG.PART: S6510-5MG
UNSPSC: 41116134
Manufacturer: Sigma-Aldrich
Product Name
N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin, ≥90% (HPLC)
assay
≥90% (HPLC)
form
powder
solubility
0.1% trifluoroacetic acid in acetonitrile: water (3:1): 1 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
CC(C)CC(NC(=O)CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc1ccc(O)cc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)
InChI key
UVFAEQZFLBGVRM-UHFFFAOYSA-N
Related Categories
Bioactive Small Molecule Inhibitors
Bioactive Small Molecules
Amino Acid Sequence
N-Suc-Leu-Leu-Val-Tyr-7-AMC
General description
Fluorogenic substrate for chymotrypsin-like enzymes, such as cathepsin B and calpain which have been implicated in programmed cell death.
Application
N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin was used in proteasome chymotrypsin-like activity assay in Jurkat cell lysate6 and crude cell lysate of rice.7
Biochem/physiol Actions
In the presence of chymotrypsin-like enzyme activity, the fluorophore, 7-amido-4-methylcoumarin is released from N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin. The fluorescence obtained is a measure of the enzyme activity.6
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
hcodes
H413
pcodes
P273
Hazard Classifications
Aquatic Chronic 4
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
PPE
Eyeshields, Gloves, type N95 (US)
| SKU | SIAL-S6510-5MG |
|---|---|
| Supplier Part Number | S6510-5MG |
| UM | EA |
| UNSPSC | 41116134 |
| Manufacturer | Sigma-Aldrich |
| Temperature | -20C |
| Refrigerated-Frozen | Y |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 10.000000 |
| Lead Time | 9 |
| CAS Number | 94367-21-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |