Sigma-Aldrich VAS2870. ≥97% (HPLC), NOX4 inhibitor, powder. 5 mg

Name: Sigma-Aldrich VAS2870. ≥97% (HPLC), NOX4 inhibitor, powder. 5 mg
SKU: SIAL-SML0273-5MG
Price: 119.48 USD

List Price $119.48 Your Price $119.48

Sigma-Aldrich VAS2870. ≥97% (HPLC), NOX4 inhibitor, powder. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-SML0273-5MG

MFG.PART: SML0273-5MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

VAS2870, ≥97% (HPLC)

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥5 mg/mL

storage temp.

room temp

SMILES string

C(c1ccccc1)n2nnc3c(Sc4nc5ccccc5o4)ncnc23

InChI

1S/C18H12N6OS/c1-2-6-12(7-3-1)10-24-16-15(22-23-24)17(20-11-19-16)26-18-21-13-8-4-5-9-14(13)25-18/h1-9,11H,10H2

InChI key

HZSOKHVVANONPV-UHFFFAOYSA-N

Application

VAS2870 has been used as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor:

to study the importance of NOX-derived reactive oxygen species in cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly[1]
to study the function of Nox2 and Nox4 in lipopolysaccharide (LPS)-induced intestinal injury in high-fat diet (HFD) fed mice[2]
to reduce the reactive oxygen species level and study its influence on inhibiting the induction of trained innate immunity in monocytes[3]

Biochem/physiol Actions

In addition to NOX4 inhibition, VAS2870 is also known to supress the reactive oxygen species (ROS) production in several cell types.[4] It effectively impairs cell growth and increases apoptosis induced by transforming growth factor β (TGF-β) in liver cancer cells. Thus, inhibition of NOX enzymes by VAS2870 may be considered as a potential therapeutic strategy for liver cancer.[5]

VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC.

VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c