Sigma-Aldrich Ibuprofen. ≥98% (GC), powder, COX inhibitor. 5 g

Name: Sigma-Aldrich Ibuprofen. ≥98% (GC), powder, COX inhibitor. 5 g
SKU: SIAL-I4883-5G
Price: 208.80 USD

List Price $208.80 Your Price $208.80

Sigma-Aldrich Ibuprofen. ≥98% (GC), powder, COX inhibitor. 5 g - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-I4883-5G

MFG.PART: I4883-5G

UNSPSC: 51000000

Manufacturer: Sigma-Aldrich

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Description

Product Name

Ibuprofen, ≥98% (GC)

biological source

synthetic (organic)

assay

≥98% (GC)

form

powder

mp

77-78 °C

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

SMILES string

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

InChI key

HEFNNWSXXWATRW-UHFFFAOYSA-N

Gene Information

human ... ALB(213), ALOX5(240), CYP1A2(1544), CYP2C9(1559), IL8RA(3577), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689)
rat ... Alox5(25290), Ptgs1(24693)

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General description

Ibuprofen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) known for its pain-relieving, anti-inflammatory, and fever-reducing properties. It can hinder the effectiveness of various antihypertensive medications, including β-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and diuretics. Ibuprofen exists in an unbound state in cerebrospinal fluid and is accumulated in the synovial fluid of inflamed joints in arthritis patients.[1]

Application

Ibuprofen has been used:

to study its vascular and pulmonary effects on neonatal lung development[2]
to study its effects on cell apoptosis, cell proliferation, and histology changes in human cholangiocarcinoma cell lines[3]
in the preparation of a terpene-based therapeutic deep eutectic system (THEDES) to investigate its physicochemical, antimicrobial, and anticancer properties[4]

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

GHS07

signalword

Warning

hcodes

H302,H319,H335

pcodes

P261 - P264 - P271 - P280 - P301 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c