Sigma-Aldrich Docetaxel. purum, ≥97.0% (HPLC). 5 mg

Name: Sigma-Aldrich Docetaxel. purum, ≥97.0% (HPLC). 5 mg
SKU: SIAL-01885-5MG-F
Price: 342.20 USD

List Price $342.20 Your Price $342.20

Sigma-Aldrich Docetaxel. purum, ≥97.0% (HPLC). 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-01885-5MG-F

MFG.PART: 01885-5MG-F

UNSPSC: 51000000

Manufacturer: Sigma-Aldrich

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Description

grade

purum

Quality Level

200

assay

≥97.0% (HPLC)

form

powder or crystals

impurities

~6% water

mp

186-192 °C (dec.)

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

[H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c6ccccc6

InChI

1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1

InChI key

ZDZOTLJHXYCWBA-VCVYQWHSSA-N

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Related Categories

Biochemicals

Chemistry & Biochemicals

Natural Products for Research and Discovery

General description

Docetaxel is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree [1], with a baccatin ring [2], and is an anthracycline antibiotic.[3] It is related to paclitaxel but structurally it differs from paclitaxel on the 3′ position of the side chain and 10′ position of the baccatin ring.[2]

Application

Docetaxel has been used:

to test its effect on lysosomal autophagic flux in gastric cancer cells[4]
in combination with stearidonic acid (SDA) to increase its efficacy and enhancing cell death in human prostate cancer cells[3]
as a microtubule-stabilizing agent in prostate and cervical cancer cells[5]
in combination with a γ-secretase inhibitor (GSI) in prostate cancer stem-like cells (PCSCs) to test its effect on the notch signaling pathway[6]

Biochem/physiol Actions

Docetaxel (DOC) is an anti-microtubule agent [1], a standard anti-cancer drug used in first-line chemotherapy treatment in many types of cancer including prostate and breast cancer.[4] It elicits a stronger effect of inhibiting angiogenesis in both in vitro and in vivo by acting on vascular endothelial growth factor (VEGF) associated with tumor cells.[1] Being involved in many key cellular processes such as cell cycle, angiogenesis, and gene expression; docetaxel interacts with many signaling pathways, such as the epidermal growth factor receptor (EGFR) pathway, Ras pathway, etc.[1]

Docetaxel is a taxane anti-cancer agent related to paclitaxel. It binds to and stabilizes the β−tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest and apoptosis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H315,H319,H341,H360D,H362,H372

pcodes

P202 - P260 - P263 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Eye Irrit. 2 - Lact. - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c