Sigma-Aldrich D-erythro-Sphingosine, N,N-Dimethyl-. 5 mg

Name: Sigma-Aldrich D-erythro-Sphingosine, N,N-Dimethyl-. 5 mg
SKU: SIAL-310500-5MG
Price: 220.40 USD

List Price $220.40 Your Price $220.40

Sigma-Aldrich D-erythro-Sphingosine, N,N-Dimethyl-. A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity.. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-310500-5MG

MFG.PART: 310500-5MG

UNSPSC: 41116113

Manufacturer: Sigma-Aldrich

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Description

Quality Level

100

assay

≥98% (TLC)

form

oil (Clear)
waxy solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

solubility

DMSO: 5 mg/mL
ethanol: soluble
methanol: soluble

shipped in

ambient

storage temp.

−20°C

SMILES string

N([C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO)(C)C

InChI

1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1

Related Categories

Bioactive Small Molecule Inhibitors

General description

A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKC

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 12 µM against PKC

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Other Notes

Cuvillier, O., et Al. 1996. Nature381, 800.
Ohta, H., et Al. 1995. Cancer Res.55, 691.
Kimura, S., et Al. 1992. Biochem. Pharmacol.44, 1585.
Hanada, K., et Al. 1991. Biochemistry30, 11682.
Igarashi, Y., et Al. 1990. J. Biol. Chem.265, 5385.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c