Sigma-Aldrich Protamine. solid. 250 mg

Name: Sigma-Aldrich Protamine. solid. 250 mg
SKU: SIAL-P4005-250MG
Price: 125.28 USD

List Price $125.28 Your Price $125.28

Sigma-Aldrich Protamine. solid. 250 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-P4005-250MG

MFG.PART: P4005-250MG

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

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Description

Product Name

Protamine from salmon, Grade IV, Histone, free(Millon test)

biological source

fish (salmon)

type

Grade IV

form

solid

impurities

Histone, free (Millon test)

solubility

H₂O: soluble, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

General description

Protamines are proteins rich in cysteine and arginine.[1] It possesses many phosphorylation sites. Salmon fish contains around 15 genes encoding protamine.[2] It is found to be localized to the sperm head.[3]

Application

Protamine from salmon has been used to avoid in vitro AT complex formation in samples from dogs pre-treated with heparin.[4] It has also been used to study the influences of external potential on adsorption of various proteins to a metal surface.[5]

Biochem/physiol Actions

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.[6]

Protamines are found to displace histones in DNA during spermatogenesis[1] in animals and plants.[2] Protamine is useful as a heparin neutralizer during heart surgery, dialysis and in many other clinical procedures.[3]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c