Sigma-Aldrich E-64d. powder, ≥98% (TLC). 1 mg

Name: Sigma-Aldrich E-64d. powder, ≥98% (TLC). 1 mg
SKU: SIAL-E8640-1MG
Price: 491.84 USD

List Price $491.84 Your Price $491.84

Sigma-Aldrich E-64d. powder, ≥98% (TLC). 1 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-E8640-1MG

MFG.PART: E8640-1MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

E-64d, protease inhibitor

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

methanol: water (1:1): 5 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C

InChI

1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

InChI key

SRVFFFJZQVENJC-IHRRRGAJSA-N

Application

E-64d has been used as a lysosomal inhibitor in human acute promyelocytic leukemia NB4 cells[1] and Huh-7 cells.[2] It has also been used as a protease inhibitor in free calcium physiological tyrode solution for perfusion into the isolated heart samples.[3]

Biochem/physiol Actions

E-64d is an epoxysuccinyl peptide and an inhibitor of cysteine protease cathepsin B,[4] calpains 1 and 2.[5] E-64d by its cathepsin B protease inhibition functionality, may serve as a potential drug for treating traumatic brain injury (TBI)[5] and Alzheimer′s disease (AD).[6] It inhibits gametocyte surface antigen resulting in a decreased oocyst production in Plasmodium falciparum.[7]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c