Sigma-Aldrich KU-55933. ≥98% (HPLC), Ataxia telangiectasia (A-T) mutated (ATM) kinase inhibitor, powder. 5 mg

Name: Sigma-Aldrich KU-55933. ≥98% (HPLC), Ataxia telangiectasia (A-T) mutated (ATM) kinase inhibitor, powder. 5 mg
SKU: SIAL-SML1109-5MG
Price: 138.04 USD

List Price $138.04 Your Price $138.04

Sigma-Aldrich KU-55933. ≥98% (HPLC), Ataxia telangiectasia (A-T) mutated (ATM) kinase inhibitor, powder. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-SML1109-5MG

MFG.PART: SML1109-5MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

KU-55933, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5

InChI

1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2

InChI key

XRKYMMUGXMWDAO-UHFFFAOYSA-N

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Application

KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.[1][2]

Biochem/physiol Actions

KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC₅₀ = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.

KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c