Sigma-Aldrich U-73122 hydrate. ≥97.5% (HPLC), phospholipase C inhibitor, powder. 5 mg

Name: Sigma-Aldrich U-73122 hydrate. ≥97.5% (HPLC), phospholipase C inhibitor, powder. 5 mg
SKU: SIAL-U6756-5MG
Price: 222.72 USD

List Price $222.72 Your Price $222.72

Sigma-Aldrich U-73122 hydrate. ≥97.5% (HPLC), phospholipase C inhibitor, powder. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-U6756-5MG

MFG.PART: U6756-5MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

U-73122 hydrate, powder

assay

≥97.5% (HPLC)

form

powder

color

off-white

solubility

ethanol: ~0.7 mg/mL
DMSO: ~0.9 mg/mL
chloroform: ~10 mg/mL
DMSO: ≤2.6 mg/mL (Achieved with heating.)
ethanol: ≤5 mg/mL (Achieved with heating.)
H₂O: insoluble

storage temp.

room temp

SMILES string

O.COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)C=CC5=O

InChI

1S/C29H40N2O3.H2O/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33;/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3;1H2/t23-,24-,25+,26+,29+;/m1./s1

Inchi Key

WCOYJDRCHHGMRK-BDEPKWELSA-N

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

U-73122 hydrate has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na⁺ channel (ENaC) function in gerbil Reissner′s membranes (RMs)[1]. U-73122 has also been used to study local calcium responses in human umbilical vein endothelial cells (HUVECs)[2].

Biochem/physiol Actions

Inhibits the hydrolysis of PPI to IP₃, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of g protein-phospholipase C activation, while remaining unaffected by production of cAMP.

Features and Benefits

This compound is featured on the Phospholipase C page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

U-73122 hydrate is soluble in ethanol (approx. 0.7 mg/mL or ≤ 5 mg/mL with heating), chloroform (approx. 10 mg/mL) and DMSO (approx. 0.9 mg/mL or ≤ 2.6 mg/mL with heating). U-73122 hydrate is insoluble in water.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c