Sigma-Aldrich Mefenamic acid. COX inhibitor. 50 g

An NSAID. Circumvents MRP-mediated multidrug resistance. Specifically and significantly potentiates the cytotoxicity of anthracyclines as well as teniposide, VP-16 and vincristine.

Mefenamic acid has been used:

• to test its hepatotoxic effect in the transgenic zebrafish cell line (LiPan)[1]
• to test its neuroprotective functionality in zebrafish embryos/larvae[2]
• in the preparation of mucoadhesive microparticles in hydrogel beads[3]

Mefenamic acid is an analgesic and anti-inflammatory drug. It acts as a cyclooxygenase (COX) enzyme inhibitor. It is hepatoxic and implicated in liver injury.[1] Contrarily, mefenamic acid elicits neuroprotection in in vivo ischemic stroke models by inhibiting cell toxicity induced by glutamate.[2] Mefenamic due its inhibitory effect on prostaglandin synthesis can be used in reducing edema and ache.[3]

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This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.