Sigma-Aldrich Deoxycholic acid. ≥99.0% (T). 25 g

Name: Sigma-Aldrich Deoxycholic acid. ≥99.0% (T). 25 g
SKU: SIAL-30960-25G
Price: 75.99 USD

List Price $75.99 Your Price $75.99

Sigma-Aldrich Deoxycholic acid. ≥99.0% (T). 25 g - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-30960-25G

MFG.PART: 30960-25G

UNSPSC: 12352211

Manufacturer: Sigma-Aldrich

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Description

biological source

ox bile

description

anionic

assay

≥99.0% (T)

form

powder

optical activity

[α]20/D +54±1°, c = 1% in ethanol

mol wt

392.57 g/mol

impurities

≤1% cholic acid (TLC)

mp

170-175 °C
171-174 °C (lit.)

functional group

carboxylic acid

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

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Related Categories

Biochemicals

Detergents - Anionic, Cationic, Zwitterionic, Anti-foaming

General description

Deoxycholic acid is an amphiphilic molecule and an important constituent of bile acid. It contains hydroxyl groups substituted at the 3α and 12α positions and a carboxyl group towards the end of the branched-chain. These moieties contribute to the hydrophilic nature of the molecule and the hydrophobic cyclopentanophenanthrene forms its center.[1]

Application

Deoxycholic acid has been used as:

a hyphal-inhibitory compound in an ex vivo assay to study the hyphal morphogenesis of Candida albicans in the gastrointestinal tract[2]
an internal standard to estimate the toxin concentration in the cell pellet[3]
a bile acid (BA) standard to quantitatively measure BA in various samples from treated mice by ultra-performance liquid chromatography triple quadrupole mass spectrometry[4]

Biochem/physiol Actions

Deoxycholic acid, due to its amphiphilicity, significantly helps to solubilize, emulsify, and absorb fat, vitamins, and cholesterol in the body.[1] High levels of intestinal deoxycholic acid might cause colorectal cancer by inducing oxidative stress and leading to DNA damage. It acts as an oncogene and pro-tumor factor.[5]

Other Notes

For the solubilization of the β-adrenergic receptor[6]

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c