Sigma-Aldrich Paclitaxel. From Taxus brevifolia, ≥95% (HPLC), anti-neoplastic , powder. 1 mg

Chemical structure: taxoide

Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs[1]. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells[2].

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase.

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

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This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Bottomless glass bottle. Contents are inside inserted fused cone.

Paclitaxel is soluble in methanol at 50 mg/mL and yields a clear, colorless solution. It is also soluble in DMSO (50 mg/mL) and ethanol.

Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.