Sigma-Aldrich 2′-Deoxyguanosine monohydrate. 99-100%, synthetic (organic), powder. 25 mg

Name: Sigma-Aldrich 2′-Deoxyguanosine monohydrate. 99-100%, synthetic (organic), powder. 25 mg
SKU: SIAL-D7145-25MG
Price: 59.51 USD

List Price $59.51 Your Price $59.51

Sigma-Aldrich 2′-Deoxyguanosine monohydrate. 99-100%, synthetic (organic), powder. 25 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)

NETA PART: SIAL-D7145-25MG

MFG.PART: D7145-25MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Product Name

2′-Deoxyguanosine monohydrate, 99-100%

biological source

synthetic (organic)

assay

99-100%

form

powder

solubility

1 M NH₄OH: 50 mg/mL, clear, colorless

SMILES string

O.NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1

InChI

1S/C10H13N5O4.H2O/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2/t4-,5+,6+;/m0./s1

InChI key

LZSCQUCOIRGCEJ-FPKZOZHISA-N

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Related Categories

Biochemicals

Nucleosides and Nucleotides

Application

2′-Deoxyguanosine monohydrate has been used as a nucleoside supplement:

to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish[1],
in tissue culture medium for deoxyribonucleotide triphosphate (dNTP) synthesis[2],
in RPMI (Roswell Park Memorial Institute)-1640 medium to eliminate the endogenous thymocytes[3]

Biochem/physiol Actions

Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphorylation (kinases) forms deoxyguanosine triphosphate (dGTP) which is used by DNA polymerases and reverse transcriptases to synthesize DNA(s).[4] Deoxyguanosine is the most electron-rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage.[5] This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.[6]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c