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Sigma-Aldrich Ru265. ≥95% (HPLC), powder, mitochondrial calcium uniporter inhibitor. 5 mg
List Price $142.68 Your Price $142.68
Sigma-Aldrich Ru265. ≥95% (HPLC), powder, mitochondrial calcium uniporter inhibitor. 5 mg - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART: SIAL-SML2991-5MG
MFG.PART: SML2991-5MG
UNSPSC: 41116113
Manufacturer: Sigma-Aldrich
Product Name
Ru265, ≥95% (HPLC)
Quality Level
100
assay
≥95% (HPLC)
form
powder
color
white to dark beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Cl[Ru](N)(N)(N)(N)n[Ru](N)(N)(N)(N)Cl
Biochem/physiol Actions
Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex that acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca2+] (mCa2+), but not cytosolic [Ca2+] (cCa2+) transient (50 ?M; HeLa) by blocking MCU-mediated mCa2+ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa2+ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal rat ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa2+ overload.
Selective mitochondrial calcium uniporter (MCU) inhibitor that blocks mitochondrial Ca2+ uptake at a >10-fold greater potency as Ru360.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
| SKU | SIAL-SML2991-5MG |
|---|---|
| Supplier Part Number | SML2991-5MG |
| UM | EA |
| UNSPSC | 41116113 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Energy Star | No |
| Green | No |
| Controlled | N |