Revvity HTRF Human IL-15 Detection Kit, 100,000 Assay Points

Human Interleukin 15 (IL-15) is a cytokine that is initially produced as a precursor that matures into a 114-amino acid glycoprotein. IL-15 is generated by multiple tissues, including the placenta, skeletal muscle, kidney, lung, heart, and monocytes/macrophages. IL-15 acts mainly on T and B cells and is a key cytokine in the development, proliferation, and survival of natural killer cells.

IL-15 binds with high affinity to the IL-15 receptor α and forms a complex with the α and γ chains of the IL-2 receptor for signal transduction. It can regulate inflammatory responses and activate NK cells during immune responses. IL-15 signaling has become a focus of interest for therapeutic interventions, especially in autoimmune diseases such as inflammatory bowel disease, systemic lupus erythematosus, inflammatory synovitis, psoriasis, diabetes mellitus, asthma bronchiale, rheumatoid arthritis, and T-cell leukemia.