Revvity HTRF Human Total CDK7 Detection Kit, 50,000 Assay Points

The Total CDK7 cellular assay monitors CDK7 protein levels.

Cyclin-dependent kinase 7 (CDK7) has dual functions in cells: CDK-activating kinase (CAK) that regulates cell cycle progression by phosphorylation of CDK1, CDK2, and CDK4/6, and is also a component of transcription factor II H (TFIIH) that regulates transcriptional initiation through phosphorylation of the RNA polymerase II C-terminal domain (CTD).

Therefore, inhibition of CDK7 has good potential for restoring a controlled cell cycle through the regulation of multiple cell cycle checkpoints, and has emerged as a new potential cancer therapy through cancer specific transcriptional regulation.