Revvity HTRF Human Phospho-LRRK2 (Ser1292) Detection Kit, 500 Assay Points

Leucine-Rich Repeat Kinase 2 (LRRK2) is a multi-domain protein that phosphorylates a subset of Rab GTPases. The LRRK2/Rab pathway operates at the interface of vesicular trafficking, lysosomal functioning, and autophagy, and thus plays a crucial role in immune response and neuroinflammation. Ser1292 autophosphorylation serves as an indicator of LRRK2 kinase activity. Pathogenic LRRK2 mutations, such as the common mutation G2019S, increase LRRK2 kinase activity, resulting in a toxic hyperactive protein that contributes to the Parkinson’s Disease (PD) phenotype. Consequently, LRRK2 inhibitors and degraders are considered promising therapeutic agents.