RevvityIVISbrite <em>Escherichia coli</em> Xen14 Bioluminescent Bacterial Strain

Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. Our bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers, e.g., lung, sepsis, meningitis, GI, and biofilm infections.

Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:

• Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well format
• Sensitivity - subtle changes in cellular viability are rapidly detected
• Inexpensive - no additional substrates needed for bacterial assays

Advantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:

• Rapid identification of lead drug candidates
• Real-time efficacy data
• May help to decrease drug failure by allowing disease relapse to be monitored in the same animal