RevvityHTRF Human and Mouse Total HSP70-1A/1B Detection Kit, 50,000 assay points

HSP70-1A and HSP70-1B, also known as HSPA1A and HSPA1B, are the major stress-inducible 70-kDa heat shock proteins. These highly conserved molecular chaperones play a critical role in maintaining protein quality control and cellular homeostasis under stressful conditions such as heat shock, oxidative stress, exposure to heavy metals, or proteotoxic drugs.

HSP70-1A/1B are also potent anti-apoptotic proteins, making them essential for the growth and survival of cancer cells. Elevated expression levels of these proteins are observed in various cancer types and are associated with poor prognosis, recurrence, and resistance to treatment. Consequently, targeting HSP70-1A/1B represents a promising strategy to sensitize tumors to therapy.

Conversely, HSP70-1A/1B have been shown to protect the brain from a range of nervous system injuries by inhibiting both cell death and immune responses. As a result, pharmaceutical compounds capable of inducing HSP70 expression are being explored as potential treatments for neurological diseases.